Publications

2024

1. System and method for adjusting hypoxia-inducible factor stabilizer treatment based on anemia modeling
   Doris Fuertinger, David J. Jörg, Gudrun Schappacher-Tilp, and Peter Kotanko
   US Patent Application 17960305 (2024)
2. System and method for attaining desired oxygen dosing based on erythropoiesis modeling
   Peter Kotanko, Ulrike Kotanko, Sabrina Casper, David J. Jörg, Gudrun Schappacher-Tilp, and Doris Fuertinger
   US Patent Application 17960560 (2024)

2023

3. Techniques for increasing red blood cell count
   Peter Kotanko, Nadja Grobe, Christoph Zaba, David J. Jörg, and Frank Gebauer
   US Patent Application 20230405201 (2023)
4. A system for determining the magnitude of the ultrafiltration volume expected in a peritoneal dialysis treatment
   Bernd Eberle, Paul Chamney, Vaibhav Maheshwari, and David J. Jörg
   WO Patent Application 2023/126465 A1 (2023)
5. Download PDF
   Mechanisms of hemoglobin cycling in anemia patients treated with erythropoiesis-stimulating agents
   David J. Jörg, Doris H. Fuertinger, and Peter Kotanko
   PLOS Computational Biology 19, e1010850 (2023) | DOI: 10.1371/journal.pcbi.1010850
   

   • Kudos: Understanding the challenges of anemia treatment through modeling

2022

6. Download PDF
   Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types
   David J. Jörg, Doris H. Fuertinger, Alhaji Cherif, David A. Bushinsky, Ariella Mermelstein, Jochen G. Raimann, and Peter Kotanko
   eLife 11, e76228 (2022) | DOI: 10.7554/eLife.76228
   

   • Press release: New model can predict best drug combinations for osteoporosis
   • eLife digest: Mix and match — A mathematical model of osteoporosis drugs suggests that certain treatment combinations could offer patients greater benefits
7. Download PDF
   The Piezo1 hypothesis of renal anemia
   Peter Kotanko, David J. Jörg, Nadja Grobe, and Christoph Zaba
   FASEB BioAdvances (2022) | DOI: 10.1096/fba.2022-00024

2020

8. Virtual osteoporosis clinic
   David J. Jörg, Doris H. Fürtinger, Alhaji Cherif, and Peter Kotanko
   WO Patent Application 2021/231374 A1 (2020)

2021

9. Download PDF
   A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis
   Toshinori Nakagawa, David J. Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D. Simons, Shosei Yoshida, and Takashi Nagasawa
   Cell Reports 37, 109875 (2021) | DOI: 10.1016/j.celrep.2021.109875

2017

10. Self-synchronizable network
    Alexandros Pollakis, Lucas Wetzel, David J. Jörg, Wolfgang Rave, Gerhard Fettweis, and Frank Jülicher
    European Patent 2957982 B1 (2017)

2021

11. Download PDF
    Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice
    Yoshiaki Nakamura, David J. Jörg, Yayoi Kon, Benjamin D. Simons, and Shosei Yoshida
    Cell Stem Cell 28, 1443–1456.E7 (2021) | DOI: 10.1016/j.stem.2021.03.016
12. Early stem cell aging in the mature brain
    Albina Ibrayeva, Maxwell Bay*, Elbert Pu*, David J. Jörg, Lei Peng, Heechul Jun, Naibo Zhang, Daniel Aaron, Congrui Lin, Galen Resler, Axel Hidalgo, Mi-Hyeon Jang, Benjamin D. Simons, and Michael A. Bonaguidi
    Cell Stem Cell 28, 955–966.E7 (2021) | DOI: 10.1016/j.stem.2021.03.018 | *equal contribution
    

    • Comment: The future belongs to those who prepare for it today (Cell Stem Cell)
13. Download PDF
    Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis
    Zhongfu Shen*, Yang Lin*, Jiajun Yang, David J. Jörg, Yuwei Peng, Xiuli Zhang, Yifan Xu, Luisirene Hernandez, Jian Ma, Benjamin D. Simons, and Song-Hai Shi
    Cell Reports 34, 108853 (2021) | DOI: 10.1016/j.celrep.2021.108853 | *equal contribution
14. Download PDF
    Stem cell populations as self-renewing many-particle systems
    David J. Jörg, Yu Kitadate, Shosei Yoshida, and Benjamin D. Simons
    Annual Review of Condensed Matter Physics 12, 135–153 (2021) | DOI: 10.1146/annurev-conmatphys-041720-125707
15. Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging
    Sara Bottes*, Baptiste N. Jaeger*, Gregor-Alexander Pilz*, David J. Jörg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav I. Korobeynyk, Izaskun Mallona, Fritjof Helmchen, François Guillemot, Benjamin D. Simons, and Sebastian Jessberger
    Nature Neuroscience 24, 225–233 (2021) | DOI: 10.1038/s41593-020-00759-4 | *equal contribution
    

    • Faculty Opinions recommended

2020

16. Download PDF
    The role of eryptosis in the pathogenesis of renal anemia: Insights from basic research and mathematical modeling
    Gabriela Ferreira Dias, Nadja Grobe, Sabrina Rogg, David J. Jörg, Roberto Pecoits-Filho, Andréa N. Moreno-Amaral, and Peter Kotanko
    Frontiers in Cell and Developmental Biology 8, 1276 (2020) | DOI: 10.3389/fcell.2020.598148

2019

17. Download PDF
    Defining the identity and dynamics of adult gastric isthmus stem cells
    Seungmin Han*, Jürgen Fink*, David J. Jörg, Eunmin Lee, Min Kyu Yum, Lemonia Chatzeli, Sebastian R. Merker, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Ronald Naumann, Ji-Hyun Lee, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E. Stange, Anna Philpott, Jong Kyoung Kim, Benjamin D. Simons, and Bon-Kyoung Koo
    Cell Stem Cell 25, 1–15 (2019) | DOI: 10.1016/j.stem.2019.07.008 | *equal contribution
    

    • Press release: Profiling the stem-cell characters in the story of stomach lining renewal
    • Press release: Defining two populations of stem cells in the gastric corpus epithelium
18. Download PDF
    The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism
    David J. Jörg, Elizabeth E. Caygill, Anna E. Hakes, Esteban G. Contreras, Andrea H. Brand, and Benjamin D. Simons
    eLife 8, e40919 (2019) | DOI: 10.7554/eLife.40919
19. Download PDF
    Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche
    Yu Kitadate, David J. Jörg, Moe Tokue, Ayumi Maruyama, Rie Ichikawa, Soken Tsuchiya, Eri Segi-Nishida, Toshinori Nakagawa, Aya Uchida, Chiharu Kimura-Yoshida, Seiya Mizuno, Fumihiro Sugiyama, Takuya Azami, Masatsugu Ema, Chiyo Noda, Satoru Kobayashi, Isao Matsuo, Yoshiakira Kanai, Takashi Nagasawa, Yukihiko Sugimoto, Satoru Takahashi, Benjamin D. Simons, and Shosei Yoshida
    Cell Stem Cell 24, 79–92 (2019) | DOI: 10.1016/j.stem.2018.11.013
    

    • Commentary: Competition for Food Drives Stem Cell Fate in Facultative Niches
    • Press release: How sperm stem cells maintain their number

2018

20. Download PDF
    Chemical event chain model of coupled genetic oscillators
    David J. Jörg, Luis G. Morelli, and Frank Jülicher
    Physical Review E 97, 032409 (2018) | DOI: 10.1103/PhysRevE.97.032409
    

    • Editor's Suggestion
21. Live imaging of neurogenesis in the adult mouse hippocampus
    Gregor-Alexander Pilz*, Sara Bottes*, Marion Betizeau, David J. Jörg, Stefano Carta, Benjamin D. Simons, Fritjof Helmchen, and Sebastian Jessberger
    Science 359, 658–662 (2018) | DOI: 10.1126/science.aao5056 | *equal contribution
    

    • Commentary: Revising concepts about adult stem cells
    • Faculty Opinions recommended
22. Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation
    Ximena Ibarra-Soria*, Wajid Jawaid*, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone, David J. Jörg, Richard C. V. Tyser, Fernando J. Calero-Nieto, Carla Mulas, Jennifer Nichols, Ludovic Vallier, Shankar Srinivas, Benjamin D. Simons, Berthold Göttgens, and John C. Marioni
    Nature Cell Biology 20, 127–134 (2018) | DOI: 10.1038/s41556-017-0013-z | *equal contribution

2017

23. Download PDF
    Amplitude bounds for biochemical oscillators
    David J. Jörg
    EPL (Europhysics Letters) 119, 58004 (2017) | DOI: 10.1209/0295-5075/119/58004
    

    • Editor's Choice and Highlight of 2017 Selected as a Highlight in Europhysics News
24. Download PDF
    Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
    Xiaoyang Lan, David J. Jörg, Florence M. G. Cavalli, Laura M. Richards, Long V. Nguyen, Robert J. Vanner, Paul Guilhamon, Lilian Lee, Michelle M. Kushida, Davide Pellacani, Nicole I. Park, Fiona J. Coutinho, Heather Whetstone, Hayden J. Selvadurai, Clare Che, Betty Luu, Annaick Carles, Michelle Moksa, Naghmeh Rastegar, Renee Head, Sonam Dolma, Panagiotis Prinos, Michael D. Cusimano, Sunit Das, Mark Bernstein, Cheryl H. Arrowsmith, Andrew J. Mungall, Richard A. Moore, Yussanne Ma, Marco Gallo, Mathieu Lupien, Trevor J. Pugh, Michael D. Taylor, Martin Hirst, Connie J. Eaves, Benjamin D. Simons, and Peter B. Dirks
    Nature 549, 227 (2017) | DOI: 10.1038/nature23666
    

    • Blurb: Tracing Cell Dynamics during Cancer Growth (Cell Systems)
    • Commentary: Stem cells — masters of their fates (Nature)
    • Commentary: A function-first look at tumor heterogeneity (Nature Methods)
    • Commentary: Order in Chaos: Understanding Intratumoral Heterogeneity in Gliomas by Tracking Tumor Cell Fate (Neurosurgery)
    • Commentary: Glioblastoma Stem Cell Clonal Dynamics Drive Intratumor Heterogeneity (Cancer Discovery)
    • Coverage: Researchers use ‘bar-coding’ system to track development of brain tumour cells (The Star)
    • Coverage: 'Barcoding' brain cancer cells helps untangle complexity, points to treatment targets (CTV News)
    • Faculty Opinions recommended
25. Download PDF
    Stochastic Kuramoto oscillators with discrete phase states
    David J. Jörg
    Physical Review E 96, 032201 (2017) | DOI: 10.1103/PhysRevE.96.032201
26. Download PDF
    Self-organized synchronization of digital phase-locked loops with delayed coupling in theory and experiment
    Lucas Wetzel, David J. Jörg, Alexandros Pollakis, Wolfgang Rave, Gerhard Fettweis, and Frank Jülicher
    PLOS ONE 12, e0171590 (2017) | DOI: 10.1371/journal.pone.0171590

2015

27. Download PDF
    Self-organized synchronisation in massive MIMO inspired by biological systems
    Lucas Wetzel, Alexandros Pollakis, David J. Jörg, Wolfgang Rave, Gerhard Fettweis, and Frank Jülicher
    IEEE Workshop 2015 – Molecular, Biological, and Multi-Scale Communications (2015)

2016

28. Download PDF
    Sequential pattern formation governed by signaling gradients
    David J. Jörg, Andrew C. Oates, and Frank Jülicher
    Physical Biology 13, 05LT03 (2016) | DOI: 10.1088/1478-3975/13/5/05LT03
    

    • Highlight of 2016
29. Download PDF
    Faster embryonic segmentation through elevated Delta-Notch signalling
    Bo-Kai Liao, David J. Jörg, and Andrew C. Oates
    Nature Communications 7, 11861 (2016) | DOI: 10.1038/ncomms11861
    

    • Faculty Opinions recommended
30. Download PDF
    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock
    Alexis B. Webb, Iván M. Lengyel, David J. Jörg, Guillaume Valentin, Frank Jülicher, Luis G. Morelli, and Andrew C. Oates
    eLife 5, e08438 (2016) | DOI: 10.7554/eLife.08438

2015

31. Download PDF
    Continuum theory of gene expression waves during vertebrate segmentation
    David J. Jörg, Luis G. Morelli, Daniele Soroldoni, Andrew C. Oates, and Frank Jülicher
    New Journal of Physics 17, 093042 (2015) | DOI: 10.1088/1367-2630/17/9/093042
32. Synchronization of mutually coupled digital PLLs in massive MIMO systems
    David J. Jörg, Alexandros Pollakis, Lucas Wetzel, Marvin Dropp, Wolfgang Rave, Frank Jülicher, and Gerhard Fettweis
    IEEE ICC 2015, 1716 (2015) | DOI: 10.1109/ICC.2015.7248572
33. Download PDF
    Nonlinear transient waves in coupled phase oscillators with inertia
    David J. Jörg
    Chaos 25, 053106 (2015) | DOI: 10.1063/1.4919831

2014

34. Download PDF
    Synchronization in networks of mutually delay-coupled phase-locked loops
    Alexandros Pollakis, Lucas Wetzel, David J. Jörg, Wolfgang Rave, Gerhard Fettweis, and Frank Jülicher
    New Journal of Physics 16, 113009 (2014) | DOI: 10.1088/1367-2630/16/11/113009
35. Download PDF
    A Doppler effect in embryonic pattern formation
    Daniele Soroldoni*, David J. Jörg*, Luis G. Morelli, David L. Richmond, Johannes Schindelin, Frank Jülicher, and Andrew C. Oates
    Science 345, 222—225 (2014) | DOI: 10.1126/science.1253089 | *equal contribution
    

    • Commentary: 'World's slowest Doppler effect' found in embryo development
    • Commentary: Timing is not only ticking: Max Planck researchers discover that a Doppler effect influences segmentation
36. Download PDF
    Synchronization dynamics in the presence of coupling delays and phase shifts
    David J. Jörg, Luis G. Morelli, Saúl Ares, and Frank Jülicher
    Physical Review Letters 112, 174101 (2014) | DOI: 10.1103/PhysRevLett.112.174101

2012

37. Download PDF
    Collective modes of coupled phase oscillators with delayed coupling
    Saúl Ares, Luis G. Morelli, David J. Jörg, Andrew C. Oates, and Frank Jülicher
    Physical Review Letters 108, 204101 (2012) | DOI: 10.1103/PhysRevLett.108.204101

Genetic Oscillations and Vertebrate Embryonic Development
Doctoral Thesis, Dresden University of Technology (2014)

On Integrating Out A Correlated Quantum Dot
Diploma Thesis, University of Heidelberg (2010)